Statins Offset Insulin-Related Cancer Risk in T2DM

Share this content:
Statins Offset Insulin-Related Cancer Risk in T2DM
Statins Offset Insulin-Related Cancer Risk in T2DM

WEDNESDAY, Oct. 26, 2016 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), use of statins offsets insulin-related cancer risks, according to research published online Oct. 21 in the Journal of Internal Medicine.

Alexandra Kautzky-Willer, M.D., from the Medical University of Vienna, and colleagues characterized all possible associations between individual T2DM therapies, statin use, and site-specific cancers in the Austrian population using medical claims data for 1,847,051 patients with hospital stays during 2006 to 2007.

The researchers found that the risk of cancers of the colon (males only), liver (males only), pancreas, lung (males only), and brain (males only) were increased up to nine-fold for patients treated with insulin or insulin secretagogues; the risk of prostate cancer was decreased strongly. The risks were generally decreased for patients taking statins, with a greater risk reduction among those not receiving antihyperglycemic therapies. The effects were strongest for use of insulin and pancreatic cancer, sulfonylureas or glitazones and skin cancer, and metformin and prostate cancer, corpus uteri, and non-Hodgkin's lymphoma.

"Overall, our data support the hyperglycemia-cancer hypothesis," the authors write. "Therefore, insulin-sparing and insulin-sensitizing drugs should be the preferred treatment choices."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

FDA Warns of Possible Heart Risks Linked to Clarithromycin

FDA Warns of Possible Heart Risks Linked to ...

Agency advising doctors to consider prescribing other antibiotics to patients with coronary heart disease

Artificial Intelligence May Help Prevent Physician Burnout

Artificial Intelligence May Help Prevent Physician Burnout

Many potential uses for AI, including improving searches and documentation, selecting treatment

Benzodiazepine Use Declining in Older Adults

Benzodiazepine Use Declining in Older Adults

Findings based on assessment of incidence, prevalence of use in three countries from 2010-2016

is free, fast, and customized just for you!

Already a member?

Sign In Now »