Squamous Cell Carcinoma Can Develop on Verrucous Lesions

This article originally appeared here.
Share this content:
Squamous Cell Carcinoma Can Develop on Verrucous Lesions
Squamous Cell Carcinoma Can Develop on Verrucous Lesions

WEDNESDAY, Oct. 14, 2015 (HealthDay News) -- Squamous cell carcinoma (SCC) can develop on long-standing verrucous lesions, according to a report published as a letter to the editor in the October issue of The Journal of Dermatology.

Shuji Suzuki, from Tottori University in Japan, and colleagues described the case of a 64-year-old woman with a nodule on her left heel for 20 years. She visited the hospital seven years before presentation with enlargement of the nodule; hyperkeratosis, acanthosis, papillomatosis, and hypergranulosis were identified on histological examination, consistent with verruca plantaris. Two months before presentation, the nodule started to grow on the weight-bearing area, with a bad smell.

The team identified a nodule with dry necrosis and ulceration. A yellowish-white granular structure surrounded by reddish reticular structures was seen on dermoscopy. Biopsied histopathology was consistent with SCC; the epidermis had been replaced with exophytic growth of atypical keratinocytes with marked surface keratinization, cancer pearls, necrotic foci, and frequent mitoses. These findings were compatible with verrucous carcinoma type SCC. The MIB-1 index was increased to 25.2 percent; immunostaining against human papillomavirus was negative. Verrucous lesions were seen adjacent to SCC.

"This is the first case of a long-standing verrucous lesion ascertained histopathologically with subsequent development of SCC," the authors write. "Frequent biopsies or excision of a non-surgical treatment-resistant verrucous lesion is necessary, particularly in patients with an immunosuppressive status or with mechanical stimulation."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

AAP: Congress Urged to Act to Prevent Firearm Deaths

AAP: Congress Urged to Act to Prevent Firearm ...

Following latest shooting, pediatricians join call for action to be taken to address firearm deaths, injury

Lung Cancer Incidence Higher for Young Women Than Young Men

Lung Cancer Incidence Higher for Young Women Than ...

Crossover in sex-specific rates among U.S. non-Hispanic whites born since 1965

E-Cigarette Flavoring Agent May Impair Airway Defense System

E-Cigarette Flavoring Agent May Impair Airway Defense System

Flavoring commonly used in e-cigarettes suppresses cilia beat frequency, lasting for 60 minutes

is free, fast, and customized just for you!

Already a member?

Sign In Now »