Some RA Treatments Up Second Nonmelanoma Skin Cancer Risk

This article originally appeared here.
Share this content:
Some RA Treatments Up Second Nonmelanoma Skin Cancer Risk
Some RA Treatments Up Second Nonmelanoma Skin Cancer Risk

THURSDAY, Oct. 29, 2015 (HealthDay News) -- For patients with rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) with prior nonmelanoma skin cancer (NMSC), the risk of second NMSC varies with different treatments, according to a study published online Oct. 28 in JAMA Dermatology.

Frank I. Scott, M.D., from the University of Pennsylvania in Philadelphia, and colleagues examined the relative hazard of a second NMSC in patients with RA or IBD who use methotrexate, anti-tumor necrosis factor (TNF) therapy, or thiopurines. Data were included for 6,841 patients with RA and 2,788 with IBD in a retrospective cohort study.

The researchers found that the incidence rates of a second NMSC were 58.2 and 58.9 per 1,000 person-years in patients with RA and IBD, respectively. Methotrexate used in conjunction with other medications correlated with increased risk of a second NMSC among patients with RA (hazard ratio, 1.60). The risk of a second NMSC increased with one year or more of methotrexate use, after adjustment for other medications (hazard ratio, 1.24). The addition of anti-TNF drugs versus methotrexate alone correlated with increased risk of NMSC (hazard ratio, 1.49). There was no correlation for abatacept and rituximab with increased NMSC risk. For IBD, the hazard ratios for one year or more of thiopurine and anti-TNF were nonsignificant.

"These data can be used to guide therapeutic decisions in patients with prior NMSC," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Both Statin, Non-Statin Therapies Effective for Lowering LDL

Both Statin, Non-Statin Therapies Effective for Lowering LDL

Dietary changes, other meds, and even surgery can lower cardiovascular risk similarly to statins

Negative Effects Seen With Video Gaming 9 Hours/Week

Negative Effects Seen With Video Gaming 9+ Hours/Week

Benefits seen with one hour a week, but behavioral problems appear to rise at nine hours a week

Improved Adult Lung Function Linked to Childhood Farm Life

Improved Adult Lung Function Linked to Childhood Farm ...

First study to report beneficial effects of growing up on a farm on adult FEV1

is free, fast, and customized just for you!

Already a member?

Sign In Now »