Solanezumab Doesn't Affect Cognitive Decline in Alzheimer's

Share this content:
Solanezumab Doesn't Affect Cognitive Decline in Alzheimer's
Solanezumab Doesn't Affect Cognitive Decline in Alzheimer's

FRIDAY, Jan. 26, 2018 (HealthDay News) -- For patients with mild Alzheimer's disease, solanezumab administered every four weeks does not alter cognitive decline, according to a study published in the Jan. 25 issue of the New England Journal of Medicine.

Lawrence S. Honig, M.D., Ph.D., from Columbia University Medical Center in New York City, and colleagues conducted a double-blind, placebo-controlled trial involving patients with mild dementia due to Alzheimer's disease. A total of 2,129 patients were enrolled and randomized to receive solanezumab (400 mg; 1,057 patients) or placebo (1,072 patients) intravenously every four weeks for 76 weeks.

The researchers found that the mean change from baseline in the score on the 14-item cognitive subscale of the Alzheimer's Disease Assessment Scale score was 6.65 and 7.44 in the solanezumab and placebo groups, respectively, with no significant difference between the groups at week 80 (difference, −0.8; 95 percent confidence interval, −1.73 to 0.14; P = 0.1). The change from baseline in the Mini-Mental State Examination score was −3.17 and −3.66 in the solanezumab and placebo groups, respectively.

"Solanezumab at a dose of 400 mg administered every four weeks in patients with mild Alzheimer's disease did not significantly affect cognitive decline," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Eli Lilly, which funded the study.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

FDA Approves First Generic Under-the-Tongue Suboxone

FDA Approves First Generic Under-the-Tongue Suboxone

May only be prescribed by Drug Addiction Treatment Act-certified prescribers

Kellogg's Honey Smacks Cereal Recalled Due to Salmonella Risk

Kellogg's Honey Smacks Cereal Recalled Due to <i>Salmonella</i> ...

Twenty-four people have been hospitalized, but no deaths have been reported

Portable Music Player Use Linked to Hearing Loss in Children

Portable Music Player Use Linked to Hearing Loss ...

Increased odds of high-frequency hearing loss with portable music player use

is free, fast, and customized just for you!




Already a member?

Sign In Now »