Smoking Ups Cancer Risk by Causing Distinct Cell Mutations

Share this content:
Smoking Ups Cancer Risk by Causing Distinct Cell Mutations
Smoking Ups Cancer Risk by Causing Distinct Cell Mutations

FRIDAY, Nov. 4, 2016 (HealthDay News) -- Tobacco smoking causes mutations that lead to cancer by multiple distinct mechanisms, according to a study published in the Nov. 4 issue of Science.

Researchers from the Los Alamos National Laboratory in New Mexico, the Wellcome Trust Sanger Institute in England, and other institutions analyzed 5,243 cancer tumors from smokers and nonsmokers.

"Before now, we had a large body of epidemiological evidence linking smoking with cancer, but now we can actually observe and quantify the molecular changes in the DNA due to cigarette smoking," co-lead author Ludmil Alexandrov, Ph.D., from the Los Alamos National Laboratory, said in a Wellcome Trust news release. "With this study, we have found that people who smoke a pack a day develop an average of 150 extra mutations in their lungs every year, which explains why smokers have such a higher risk of developing lung cancer."

Tumors from other parts of the body also contained smoking-related mutations, the scientists found. For example, smoking a pack a day led to a yearly average of 97 mutations in each cell in the larynx, 39 mutations for the pharynx, 23 mutations for the mouth, 18 mutations for the bladder, and six mutations in every cell of the liver.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »