Smokers More Prone to Relapse After Crohn's Surgery

Share this content:
Smokers More Prone to Relapse After Crohn's Surgery
Smokers More Prone to Relapse After Crohn's Surgery

FRIDAY, Sept. 2, 2016 (HealthDay News) -- Smoking increases the risk that Crohn's disease patients will experience clinical recurrence after bowel surgery, according to research published online Aug. 30 in The Lancet Gastroenterology and Hepatology.

The study included 240 Crohn's disease patients in the United Kingdom who were followed for three years after bowel surgery. The investigators also assessed whether mercaptopurine is effective in prevention of relapse after surgery.

Clinical recurrence was found to be significantly more common in smokers. The team also found mercaptopurine effective in preventing postoperative clinical recurrence of Crohn's disease, but only in smokers.

"Treatment with mercaptopurine to delay or prevent postoperative recurrence was particularly effective in people who continue to smoke; thus, in smokers, thiopurine treatment seems to be justified in the early postoperative period," the authors conclude. "In non-smokers, the data do not provide a sufficiently strong rationale for immediate initiation of treatment in the postoperative period. A considered approach involving colonoscopy in the first six to 12 months is likely to be beneficial in this group."

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

900 Steps Tied to Functional Decline in Hospitalized Seniors

<900 Steps Tied to Functional Decline in Hospitalized ...

Walking <900 steps/day linked to hospitalization-associated functional decline

Thromboprophylaxis Not Effective After Knee Arthroplasty, Casting

Thromboprophylaxis Not Effective After Knee Arthroplasty, Casting

Does not prevent venous thromboembolism after knee arthroplasty, casting of lower leg

ASH: Lower Rate of Sickle Cell Pain Crises With Crizanlizumab

ASH: Lower Rate of Sickle Cell Pain Crises ...

Lower rate of crises per year; longer median time to first, second crises with high-dose therapy

is free, fast, and customized just for you!

Already a member?

Sign In Now »