Smart Extendin-4 Delivery Device Promising for Type 2 Diabetes

Share this content:
Smart Extendin-4 Delivery Device Promising for Type 2 Diabetes
Smart Extendin-4 Delivery Device Promising for Type 2 Diabetes

TUESDAY, Jan. 2, 2018 (HealthDay News) -- A smart extendin-4 (Ex4) delivery device is a promising therapeutic option for type 2 diabetes that can provide safe, long-term, and on-demand Ex4 therapy, according to a study published online Nov. 24 in Nature Communications.

Noting that delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs, Wei Chen, Ph.D., from Sun Yat-sen University Cancer Center in Guangzhou, China, and colleagues examined the role of a smart Ex4 delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles that separately contain Ex4 and glucose oxidase (GOx) for diabetes therapy.

The researchers found that as a result of the differential response to the microenvironment induced by biological stimuli, the dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx. Thereby the system allows glucose-responsive and closed-loop release to significantly improve the therapeutic performance of Ex4. The mechanical strength of alginate-based MN can be enhanced by integration of mineralized particles by crosslinking to facilitate skin penetration, supporting transdermal administration that is painless and noninvasive.

"We believe this smart glucose-responsive Ex4 delivery holds great promise for type 2 diabetes therapy by providing safe, long-term, and on-demand Ex4 therapy," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters


More in Home

Study Finds 31 Percent Use No Opioids After Surgery

Study Finds 31 Percent Use No Opioids After ...

At discharge, 92.2 percent of patients received an opioid prescription; nearly 63 percent unused

PAs May Have Lower Diagnostic Accuracy for Melanoma

PAs May Have Lower Diagnostic Accuracy for Melanoma

PAs diagnose fewer melanomas in situ, perform more skin biopsies per case of skin cancer diagnosed

AAN: Neuromodulation Therapy Gives Relief From Hand Tremor

AAN: Neuromodulation Therapy Gives Relief From Hand Tremor

Non-invasive neuromodulation therapy using a custom stimulation pattern safe for essential tremor

is free, fast, and customized just for you!

Already a member?

Sign In Now »