Sleep Disturbance Linked to Esophageal Hypersensitivity

Share this content:
Sleep Disturbance Linked to Esophageal Hypersensitivity
Sleep Disturbance Linked to Esophageal Hypersensitivity

MONDAY, Dec. 5, 2016 (HealthDay News) -- For patients with gastroesophageal reflux disease (GERD), sleep disturbance is associated with enhanced heartburn perception to capsaicin infusion, according to a study published online Nov. 29 in the Journal of Gastroenterology and Hepatology.

Chih-Hsun Yi, M.D., from the Hualien Tzu Chi Hospital in Taiwan, and colleagues examined whether sleep disturbance modulates esophageal sensitivity to capsaicin infusion in patients with GERD. Forty patients were enrolled and underwent sleep quality measurement by the Pittsburg Sleep Quality Index. The authors documented esophageal sensation to capsaicin infusion by measuring lag time to initial heartburn perception, heartburn intensity rating, and sensitivity score based on esophageal infusion of capsaicin-containing sauce.

The researchers found that 22 patients had sleep disturbance, and they experienced a shorter lag time to initial heartburn perception and greater sensory intensity rating (P = 0.03 and P = 0.02, respectively). Compared to those without sleep disturbance, patients with sleep disturbance had greater sensitivity score for capsaicin infusion (P = 0.04). Patients with sleep disturbance also had poor sleep efficiency (P = 0.04), longer average awakening time (P = 0.03), and greater total activity account (P = 0.04) in actigraphy measures. There was a positive correlation for the lag time for perceiving capsaicin infusion with total sleep time (P = 0.03).

"Our findings suggest that sleep disturbance is associated with esophageal hypersensitivity to capsaicin infusion in patients with GERD," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »