Similar Outcomes for Bivalirudin, Heparin in STEMI With PCI

Share this content:
Similar Outcomes for Bivalirudin, Heparin in STEMI With PCI
Similar Outcomes for Bivalirudin, Heparin in STEMI With PCI

FRIDAY, May 19, 2017 (HealthDay News) -- Similar outcomes are seen for use of bivalirudin and heparin as anticoagulant agents in patients with ST-segment elevation myocardial infarction (STEMI) treated with radial primary percutaneous coronary intervention (PCI), according to a study published online May 17 in JACC: Cardiovascular Interventions.

Ion S. Jovin, M.D., Sc.D., from Virginia Commonwealth University in Richmond, and colleagues compared outcomes for patients with STEMI who underwent primary PCI via radial access and received bivalirudin or heparin as anticoagulation agents (29,660 and 37,708 patients, respectively).

The researchers observed no significant difference in the rate of the composite end point of death, myocardial infarction, or stroke in the unadjusted comparison (4.6 versus 4.7 percent; P = 0.47). The rate of acute stent thrombosis was significantly higher with bivalirudin versus heparin (1.00 versus 0.6 percent; P < 0.001). The odds ratio for the composite end point of death, myocardial infarction, or stroke was 0.95 (95 percent confidence interval, 0.87 to 1.05; P = 0.152) for bivalirudin versus heparin, after adjustment for multiple variables, including for a propensity score; the odds ratio for acute stent thrombosis was 2.11 (95 percent confidence interval, 1.73 to 2.57; P < 0.001). There was no significant difference noted in major bleeding rates.

"In patients undergoing primary PCI via transradial access anticoagulated with bivalirudin or heparin, there was no difference in the composite end point of death, myocardial infarction, or stroke," the authors write.

Two authors disclosed financial ties to the pharmaceutical and medical device industries.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Surveillance Frequency Doesn't Cut Mortality in Colorectal Cancer

Surveillance Frequency Doesn't Cut Mortality in Colorectal Cancer

And, intensity of imaging surveillance not linked to time to detection of colorectal cancer recurrence

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower RTI

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower ...

Provision of assay doesn't result in less antibiotic use for suspected lower respiratory tract infection

Preventing Child Maltreatment Not Yet Feasible in Primary Care

Preventing Child Maltreatment Not Yet Feasible in Primary ...

USPSTF says evidence inadequate for primary care interventions to prevent child maltreatment

is free, fast, and customized just for you!

Already a member?

Sign In Now »