Similar Adverse Event Risk for Typical, Atypical Antipsychotics

Share this content:
Similar Adverse Event Risk for Typical, Atypical Antipsychotics
Similar Adverse Event Risk for Typical, Atypical Antipsychotics

WEDNESDAY, Feb. 15, 2017 (HealthDay News) -- The risks of adverse events are similar with short-term use of typical and atypical antipsychotic medications (APMs) after cardiac surgery in seniors, according to a study published online Feb. 10 in the Journal of the American Geriatrics Society.

Dae H. Kim, M.D., M.P.H., Sc.D., from the Brigham and Women's Hospital in Boston, and colleagues conducted a retrospective cohort study involving individuals (mean age, 70 years) undergoing coronary artery bypass grafting or valve surgery (3,706 patients). Participants were either newly treated with oral atypical (2,580 patients) or typical (1,126 patients) APMs.

The researchers found that the median treatment duration was three and two days, respectively, for atypical and typical APMs, in the propensity score-matched cohort. No large differences were seen for atypical versus typical cohorts in in-hospital mortality (5.4 versus 5.3 percent; risk difference [RD], 0.1 percent; 95 percent confidence interval [CI], −2.1 to 2.3 percent), arrhythmia (2.0 versus 2.2 percent; RD, 0.0 percent; 95 percent CI, −1.4 to 1.4 percent), pneumonia (16.1 versus 14.5 percent; RD, 1.6 percent; 95 percent CI, −1.9 to 5.0 percent), and length of stay (9.9 versus 9.3 days, mean difference, 0.5 days; 95 percent CI, −1.2 to 2.2). Compared with typical APMs, use of brain imaging was more common after initiating atypical APMs (17.3 versus 12.4 percent; RD, 4.9 percent; 95 percent CI, 1.4 to 8.4).

"More research in a larger sample of individuals undergoing different surgeries is needed to confirm these findings," the authors write.

Two authors disclosed ties to the nonprofit educational organization Alosa Foundation; two authors disclosed ties to the biopharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »