Signature ID'd for Allergen-Specific Type 2 Helper Cells

Share this content:
Signature ID'd for Allergen-Specific Type 2 Helper Cells
Signature ID'd for Allergen-Specific Type 2 Helper Cells

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- In research published in the Aug. 2 issue of Science Translational Medicine, scientists have identified a human type 2 helper (TH2) cell signature in allergen-specific TH2 cells.

Noting that use of atopic disease-causing T cells as therapeutic targets and clinically useful biomarkers is limited by lack of an accepted methodology to identify and differentiate these cells from nonpathogenic TH2 cell types, Erik Wambre, Ph.D., from the Benaroya Research Institute in Seattle, and colleagues present data on a subset of human memory TH2 cells confined to atopic individuals that included all allergen-specific TH2 cells.

The researchers found that the subset of cells was made up of terminally differentiated CD4+ T cells, which were characterized by coexpression of CRTH2, CD49d, and CD161; they also exhibited functional attributes that were distinct from conventional TH2 cells. Cells with this allergic disease-related phenotype were designated as the TH2A cell subset. In transcriptome analysis, a distinct pathway was identified in the initiation of pathogenic responses to allergen; elimination of these cells indicated immunotherapy-induced clinical responses.

"Together, these findings identify a human TH2 cell signature in allergic diseases that could be used for response-monitoring and designing appropriate immunomodulatory strategies," the authors write.

Two authors are listed as inventors on patents held or submitted by the Benaroya Research Institute.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Osimertinib Tops Standard EGFR-TKI for EGFR NSCLC

Osimertinib Tops Standard EGFR-TKI for <i>EGFR</i>&#43; NSCLC

Significantly longer median progression-free survival for osimertinib in previously untreated NSCLC

Distinct Features for Drug Use-Related Endophthalmitis

Distinct Features for Drug Use-Related Endophthalmitis

Injection drug users have fewer comorbidities and more improvement in visual acuity after intervention

Dating Violence Victimization, Nonmedical Rx Med Use Linked

Dating Violence Victimization, Nonmedical Rx Med Use Linked

Nonmedical use of prescription drugs linked to dating violence for male, female high school students

is free, fast, and customized just for you!

Already a member?

Sign In Now »