Sickle Cell Trait Doesn't Up Mortality Risk in U.S. Soldiers

Share this content:
Sickle Cell Trait Doesn't Up Mortality Risk in U.S. Soldiers
Sickle Cell Trait Doesn't Up Mortality Risk in U.S. Soldiers

WEDNESDAY, Aug. 3, 2016 (HealthDay News) -- Sickle cell trait is not associated with a higher risk of death than absence of the trait, but it is associated with a significantly increased risk of exertional rhabdomyolysis, according to a study published in the Aug. 4 issue of the New England Journal of Medicine.

D. Alan Nelson, Ph.D., from the Stanford University School of Medicine in California, and colleagues examined whether the risks of exertional rhabdomyolysis and death varied according to sickle cell trait status. Data were included for 47,944 black soldiers who had undergone hemoglobin AS testing and were on active duty in the U.S. Army.

The researchers found that the risk of death did not differ significantly for soldiers with versus those without the sickle cell trait (hazard ratio [HR], 0.99; 95 percent confidence interval [CI], 0.46 to 2.13); however, the trait correlated with significantly elevated adjusted risk of exertional rhabdomyolysis (HR, 1.54; 95 percent CI, 1.12 to 2.12). The magnitude of this effect was similar to that associated with tobacco use versus non-use (HR, 1.54; 95 percent CI, 1.23 to 1.94) and to that associated with having a body mass index of 30 kg/m² or more versus less than 25 kg/m² (HR, 1.39; 95 percent CI, 1.04 to 1.86). The effect was less than that associated with recent statin use or antipsychotic agent use.

"Sickle cell trait was not associated with a higher risk of death than absence of the trait, but it was associated with a significantly higher risk of exertional rhabdomyolysis," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Clinician Awareness of Exercise Addiction May Be Lacking

Clinician Awareness of Exercise Addiction May Be Lacking

Screening questions should focus on emotional connection to exercise, whether it interferes with life

Overall Vagotomy Not Linked to Risk of Parkinson's Disease

Overall Vagotomy Not Linked to Risk of Parkinson's ...

But there is a trend toward lower risk of Parkinson's for patients with truncal vagotomy

Pediatricians Missing Elevated Blood Lead Levels in U.S.

Pediatricians Missing Elevated Blood Lead Levels in U.S.

In 23 of 39 reporting states, pediatric care providers identified fewer than half of children with EBLL

is free, fast, and customized just for you!

Already a member?

Sign In Now »