Shift Work May Affect the Body's Ability to Repair DNA Damage

Share this content:
Shift Work May Affect the Body's Ability to Repair DNA Damage
Shift Work May Affect the Body's Ability to Repair DNA Damage

TUESDAY, June 27, 2017 (HealthDay News) -- Capacity to repair everyday damage to cell DNA could be impaired in people who work the night shift, which may be due to melatonin suppression, according to a study published online June 26 in Occupational & Environmental Medicine.

Parveen Bhatti, Ph.D., of the Fred Hutchinson Cancer Research Center in Seattle, and colleagues built on earlier research of 223 shift workers. There, the researchers found that workers' 8-hydroxydeoxyguanosine (8-OH-dG) levels were lower during day sleep, versus night sleep. The researchers also saw evidence that lower melatonin levels correlated with lower 8-OH-dG. The 50 workers in the latest study were those who'd shown the biggest drop in melatonin during night work versus night sleep.

In the new study, the research team found that levels of 8-OH-dG during night work were 20 percent of those observed during night sleep. Circulating melatonin levels were also lower during night work versus night sleep.

"This study suggests that night work, relative to night sleep, is associated with reduced repair of 8-OH-dG lesions in DNA and that the effect is likely driven by melatonin suppression occurring during night work relative to night sleep," the authors write. "If confirmed, future studies should evaluate melatonin supplementation as a means to restore oxidative DNA damage repair capacity among shift workers."

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »