SFRP4 Linked to Impaired Glucose Tolerance, T2DM

Share this content:
SFRP4 Linked to Impaired Glucose Tolerance, T2DM
SFRP4 Linked to Impaired Glucose Tolerance, T2DM

MONDAY, Aug. 1, 2016 (HealthDay News) -- Secreted frizzled-related protein 4 (SFRP4) is associated with impaired glucose tolerance (IGT) and type 2 diabetes (T2D), according to a report published online July 6 in Diabetes Care.

Kaviya Anand, from the Madras Diabetes Research Foundation in Chennai, India, and colleagues reported on the systemic levels of SFRP4 and its correlation with insulin resistance and β-cell dysfunction in 100 individuals with normal glucose tolerance (NGT), 60 with IGT, and 100 with T2D.

The researchers found that circulatory SFRP4 levels were highest in T2D, followed by IGT and NGT (57 ± 7 ng/mL; 40 ± 4 ng/mL; and 27 ± 2 ng/mL, respectively). There were positive correlations between SFRP4 levels and age, homeostatic model assessment-insulin resistance, fasting plasma glucose, fasting insulin, glycated hemoglobin, and serum triglycerides; an inverse correlation was seen for the oral disposition index (DIo). After adjustment for age, sex, waist circumference, glycated hemoglobin, and DIo, higher levels of SFRP4 were independently associated with IGT and T2D (odds ratios per standard deviation, 1.39 and 2.62, respectively).

"These findings suggest that elevated SFRP4 may be a good marker of β-cell dysfunction and insulin resistance," the authors write. "Longitudinal studies with serial measurements of SFRP4 need to be done at different stages of insulin resistance, IGT, and T2D to understand the precise pathophysiological mechanisms involved."

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »