Sex Hormone-Sensitive Gene Complex Implicated in PMDD

Share this content:
Sex Hormone-Sensitive Gene Complex Implicated in PMDD
Sex Hormone-Sensitive Gene Complex Implicated in PMDD

TUESDAY, Jan. 3, 2017 (HealthDay News) -- The activity of certain genes are associated with premenstrual dysphoric disorder (PMDD), according to a study published online Jan. 3 in Molecular Psychiatry.

Researchers analyzed lymphoblastoid cell line cultures from women with PMDD and asymptomatic controls utilizing whole-transcriptome sequencing during untreated (ovarian steroid-free) conditions and following hormone treatment.

The researchers found that women with PMDD manifested ovarian steroid-triggered behavioral sensitivity during a hormone suppression and addback clinical trial, and controls did not. They also found that more than half of Extra Sex Combs/Enhancer of Zeste (ESC/E[Z]) genes were over-expressed in PMDD patients' cells versus cells from controls. However, protein expression of four key genes was found to be decreased in cells from women with PMDD. Progesterone was found to increase expression of several of these genes in controls. Estrogen decreased expression in cell lines of PMDD patients.

The link "adds to evidence that PMDD is a disorder of cellular response to estrogen and progesterone," study author Peter Schmidt, M.D., of the U.S. National Institutes of Health's National Institute of Mental Health, said in an agency news release. "For the first time, we now have cellular evidence of abnormal signaling in cells derived from women with PMDD, and a plausible biological cause for their abnormal behavioral sensitivity to estrogen and progesterone."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Proinflammatory Diet Linked to Increased Colorectal Cancer Risk

Proinflammatory Diet Linked to Increased Colorectal Cancer Risk

Higher empirical dietary inflammatory pattern score linked to increased risk of CRC for men and women

Longer Duration of Post-Op Opioid Use Associated With Misuse

Longer Duration of Post-Op Opioid Use Associated With ...

Higher dose, shorter duration Rx may minimize risk of longer term misuse, authors say

Alcohol Induced DNA Repair Genes Prognostic in Gastric Cancer

Alcohol Induced DNA Repair Genes Prognostic in Gastric ...

BRF1, BRCA1/2, MPO induced by alcohol have prognostic value for patients with gastric cancer

is free, fast, and customized just for you!

Already a member?

Sign In Now »