Serum Periostin IDs Comorbid Chronic Rhinosinusitis in Asthma

This article originally appeared here.
Share this content:
Serum Periostin IDs Comorbid Chronic Rhinosinusitis in Asthma
Serum Periostin IDs Comorbid Chronic Rhinosinusitis in Asthma

TUESDAY, March 21, 2017 (HealthDay News) -- For patients with asthma, serum periostin is useful for detecting chronic rhinosinusitis with nasal polyps, according to a study published online March 1 in the Annals of the American Thoracic Society.

Takamitsu Asano, M.D., from the Nagoya City University Graduate School of Medical Sciences in Japan, and colleagues examined the utility of serum periostin as a diagnostic biomarker for upper airway disease in patients with asthma. Sixty-five patients with stable asthma were enrolled: 20 without upper airway disease, 22 with rhinitis, and 23 with chronic rhinosinusitis (13 with and 10 without nasal polyps). Serum periostin, eotaxin, total immunoglobulin E, fractional exhaled nitric oxide, and blood-sputum eosinophil levels were measured.

The researchers found that patients with asthma with chronic rhinosinusitis had higher serum periostin levels than those without upper airway disease (109.6 ± 47.4 ng/mL versus 83.2 ± 22.9 ng/mL; P = 0.04). Patients with asthma with chronic rhinosinusitis and nasal polyps had higher serum periostin levels than those without nasal polyps (130.0 ± 46.6 ng/mL versus 87.9 ± 37.7 ng/mL; P = 0.001). There was no correlation for serum periostin levels with the presence or severity of rhinitis. Receiver operating curve analyses showed moderate and high diagnostic accuracy for detecting chronic rhinosinusitis and chronic rhinosinusitis with nasal polyps, respectively (area under the curve, 0.71 and 0.86, respectively). Serum periostin was the only biomarker that detected the presence of nasal polyps when comparing patients with comorbid chronic rhinosinusitis and nasal polyps to those without.

"Serum periostin is useful for detecting chronic rhinosinusitis with nasal polyps and predicting radiological chronic rhinosinusitis severity in patients with asthma," the authors write.

The study was funded by research grants from pharmaceutical companies.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »