Sertraline May Help Prevent Depressive Disorders After TBI

This article originally appeared here.
Share this content:
Sertraline May Help Prevent Depressive Disorders After TBI
Sertraline May Help Prevent Depressive Disorders After TBI

WEDNESDAY, Sept. 14, 2016 (HealthDay News) -- Sertraline seems to be efficacious for preventing depressive disorders after traumatic brain injury (TBI), according to a study published online Sept. 14 in JAMA Psychiatry.

Ricardo E. Jorge, M.D., from the Baylor College of Medicine in Houston, and colleagues conducted a placebo-controlled trial at a university hospital with 24-week follow-up. A total of 534 patients (aged 18 to 85 years) hospitalized for mild, moderate, or severe TBI were eligible for the study; 94 of these were randomized to either placebo (46 patients) or sertraline (48 patients). Seventy-nine patients completed the study.

The researchers found that to prevent depression at 24 weeks after TBI, the number needed to treat was 5.9 for sertraline treatment versus placebo (P = 0.03). Sertraline had no influence in the course of neuropsychological variables. The intervention was well tolerated, with mild adverse effects in both the sertraline and placebo groups.

"Future studies should replicate these findings in a large sample of patients with TBI and depict their long-term physical, cognitive, behavioral, and functional outcomes," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Single-Payer Health System Bill Moves Forward in California

Single-Payer Health System Bill Moves Forward in California

Not yet clear where money for the single-payer system would come from

Regorafenib Approved for Hepatocellular Carcinoma

Regorafenib Approved for Hepatocellular Carcinoma

It is the first approved treatment for HCC in almost a decade

Three Anti-VEGF Treatments Effective for Diabetic Retinopathy

Three Anti-VEGF Treatments Effective for Diabetic Retinopathy

Rates of worsening low in patients receiving aflibercept, bevacizumab, or ranibizumab

is free, fast, and customized just for you!

Already a member?

Sign In Now »