Serotonin Directly Implicated in Rheumatoid Arthritis

This article originally appeared here.
Share this content:
Serotonin Directly Implicated in Rheumatoid Arthritis
Serotonin Directly Implicated in Rheumatoid Arthritis

MONDAY, March 14, 2016 (HealthDay News) -- Serotonin appears to be involved in autoimmune arthritis through Th17 immunity and bone resorption, according to an experimental study published online March 8 in The American Journal of Pathology.

Yasmine Chabbi-Achengli, from the INSERM Unité Mixte de Recherche 1132 in Paris, and colleagues examined serotonin's involvement during collagen-induced arthritis in wild-type and Tph1−/− mice that have decreased levels of peripheral serotonin.

The researchers found that induction of arthritis triggered a robust increase in serotonin content in the paws and less inflammation in wild-type mice. There was a marked increase observed in the clinical and pathologic arthritis scores in Tph1−/− mice with arthritis. Specifically, there was a significant increase in osteoclast differentiation and bone resorption with an increase in interleukin (IL)-17 noted in the paws and in the Th17 lymphocytes of the draining lymph nodes in Tph1−/− mice; in contrast, T-regulatory cells were dampened. In Tph1−/− mice, ex vivo serotonin and agonists of the 5-HT2A and 5-HT2B receptors restored IL-17 secretion from splenocytes and Th17 cell differentiation.

"These findings indicate that serotonin plays a fundamental role in arthritis through the regulation of the Th17/ T-regulatory cell balance and osteoclastogenesis," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

ASTRO: No Survival Benefit for Adding EBT to Brachytherapy

ASTRO: No Survival Benefit for Adding EBT to ...

Addition of external beam therapy doesn't improve five-year progression-free survival in prostate cancer

ASTRO: Fewer Side Effects With IMRT in Cervical, Endometrial CA

ASTRO: Fewer Side Effects With IMRT in Cervical, ...

Patients in conventional radiotherapy arm had more high-level adverse events than those in IMRT arm

Many Doctors Reluctant to Reveal Mental Health Issues

Many Doctors Reluctant to Reveal Mental Health Issues

Perceived stigma, fear of career repercussions hinder treatment, study suggests

is free, fast, and customized just for you!

Already a member?

Sign In Now »