Screening, Therapy Effect Varies by Breast CA Molecular Subtype

Share this content:
Screening, Therapy Effect Varies by Breast CA Molecular Subtype
Screening, Therapy Effect Varies by Breast CA Molecular Subtype

TUESDAY, Jan. 9, 2018 (HealthDay News) -- The contributions of screening and treatment to decreases in breast cancer mortality vary by molecular subtype, according to a study published in the Jan. 9 issue of the Journal of the American Medical Association.

Sylvia K. Plevritis, Ph.D., from Stanford University in California, and colleagues examined the contributions of screening and treatment to breast cancer mortality reductions by molecular subtype based on estrogen-receptor (ER) and human epidermal growth factor receptor 2 (ERBB2) in women aged 30 to 79 years.

The researchers found that the estimated reduction in the overall breast cancer mortality rate was 37 percent in 2000 relative to the estimated baseline rate of 64 deaths per 100,000 women; of this reduction, 44 and 56 percent were associated with screening and treatment, respectively. The estimated reduction in overall breast cancer mortality rate was 49 percent in 2012 relative to the estimated baseline rate of 63 deaths per 100,000 women; 37 and 63 percent of this reduction were associated with screening and treatment, respectively. There was variation in the estimated relative contributions associated with screening versus treatment by molecular subtype: 36 versus 64 percent for ER+/ERBB2−, 31 versus 69 percent for ER+/ERBB2+, 40 versus 60 percent for ER−/ERBB2+, and 48 versus 52 percent for ER−/ERBB2−.

"Decreases in overall breast cancer mortality from 2000 to 2012 were associated with advances in screening and in adjuvant therapy, although the associations varied by breast cancer molecular subtype," the authors write.

Several authors disclosed financial ties to the biotechnology and statistics research industries.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »