Scientists Pinpoint Potential Drug Target for Zika Virus

This article originally appeared here.
Share this content:
Scientists Pinpoint Potential Drug Target for Zika Virus
Scientists Pinpoint Potential Drug Target for Zika Virus

MONDAY, June 20, 2016 (HealthDay News) -- A potential way to prevent Zika and similar viruses from spreading in the body has been identified, according to research published online June 17 in Nature.

"We wanted to find out if we could identify genes present in the host cells that are absolutely required by the virus for infection," senior author Michael Diamond, M.D., Ph.D., the Herbert S. Gasser Professor of Medicine at the Washington University School of Medicine in St. Louis, said in a university news release.

Diamond's team pinpointed a gene pathway that is vital for Zika and related viruses to spread infection between cells. They found that shutting down a single gene in this pathway prevents these viruses from leaving an infected cell. The discovery suggests a potential target for new drugs to fight Zika and other flaviviruses such as dengue and West Nile.

"Out of about 19,000 genes that we looked at, we only found nine key genes that the virus relies on for infection or to spread," Diamond said. "All of [the nine] are associated with an important part of the cell that processes viral particles, which is essential to spreading the infection." Of those nine genes, disabling one called SPCS1 reduced viral infection but appeared to have no harmful effects on human cells.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Ultraviolet B Radiation Exposure Tied to Decreased Risk of Myopia

Ultraviolet B Radiation Exposure Tied to Decreased Risk ...

More exposure to sun's UVB rays between ages 14 and 29 linked to lower risk

Vitamin D in Pregnancy Might Help Prevent MS in Offspring

Vitamin D in Pregnancy Might Help Prevent MS ...

Infants born with low levels of vitamin D may be more likely to develop multiple sclerosis later in life

Dabigatran May Be Better Than Warfarin After Bleeding Episode

Dabigatran May Be Better Than Warfarin After Bleeding ...

Resuming any anticoagulant found safer than stopping the drugs in these cases

is free, fast, and customized just for you!

Already a member?

Sign In Now »