SCCM: Hypothermia No Benefit After Pediatric Cardiac Arrest

This article originally appeared here.
Share this content:
SCCM: Hypothermia No Benefit After Pediatric Cardiac Arrest
SCCM: Hypothermia No Benefit After Pediatric Cardiac Arrest

WEDNESDAY, Jan. 25, 2017 (HealthDay News) -- Therapeutic hypothermia is not associated with significant benefit in survival with favorable functional outcome among comatose children who survive in-hospital cardiac arrest, according to a study published online Jan. 24 in the New England Journal of Medicine. The research was published to coincide with the annual Society of Critical Medicine's Critical Care Congress, held from Jan 21 to 25, Honolulu.

Frank Moler, M.D., from the University of Michigan Health System in Ann Arbor, and colleagues conducted a trial at 37 children's hospitals to compare two temperature interventions in children with in-hospital cardiac arrest. Comatose children older than 48 hours and younger than 18 years were randomized to therapeutic hypothermia or therapeutic normothermia.

After randomization of 329 patients, the trial was terminated because of futility. Among the 257 patients with a Vineland Adaptive Behavior Scales, second edition (VABS-II) score of at least 70 before cardiac arrest and who could be evaluated, the researchers observed no significant difference between the hypothermia and normothermia groups in terms of the primary efficacy outcome (survival at 12 months after cardiac arrest with a score of 70 or higher on the VABS-II) (36 versus 39 percent, respectively; relative risk, 0.92; 95 percent confidence interval, 0.67 to 1.27; P = 0.63).

"Among comatose children who survived in-hospital cardiac arrest, therapeutic hypothermia, as compared with therapeutic normothermia, did not confer a significant benefit in survival with a favorable functional outcome at one year," the authors write.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Saturday Is National Prescription Drug Take Back Day

Saturday Is National Prescription Drug Take Back Day

Unused medications can be dropped off at local collection sites between 10 a.m. and 2 p.m.

Multiple Myeloma Risk May Be Up for WTC-Exposed Firefighters

Multiple Myeloma Risk May Be Up for WTC-Exposed ...

And, cancer burden projected to be greater than expected for world trade center-exposed firefighters

Pros and Cons for E-Cigarettes As Aid to Smoking Cessation

Pros and Cons for E-Cigarettes As Aid to ...

Researchers present evidence supporting their use, and discuss the limits and hazards of use

is free, fast, and customized just for you!

Already a member?

Sign In Now »