Salicylates Reduce Metabolic Clearance of Insulin

This article originally appeared here.
Share this content:
Salicylates Reduce Metabolic Clearance of Insulin
Salicylates Reduce Metabolic Clearance of Insulin

MONDAY, Feb. 23, 2015 (HealthDay News) -- Salsalate increases insulin concentrations by decreasing metabolic clearance of insulin (MCI), not by increasing insulin secretion, according to research published online Feb. 13 in Diabetes, Obesity and Metabolism.

Adela Penesova, M.D., Ph.D., of the Slovak Academy of Sciences in Bratislava, Slovakia, and colleagues conducted a substudy in 27 obese individuals without diabetes who were enrolled in a randomized, double-blind, parallel, placebo-controlled clinical trial. Participants were randomly assigned to receive salsalate (16 individuals) or placebo (11 individuals). Baseline and follow-up stepped glucose infusion (SGI) was performed, and the effect of salsalate on insulin was examined.

The researchers found that during SGI in the salsalate group, C-peptide concentrations decreased by 11 percent, and plasma insulin concentrations increased by 30 percent; this corresponded to a 30 percent reduction in MCI (P < 0.0001). At molar increments of glucose, insulin concentrations were increased by 27 percent (P = 0.02), but insulin secretion rate remained unchanged.

"In conclusion, salsalate did not alter insulin secretion, but lowered MCI, indicating that reduction in insulin clearance is a principal mechanism for increased insulin levels after salicylates administration," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »