Risk Score Could Help ID Alzheimer's Risk in Young Adults

This article originally appeared here.
Share this content:
Risk Score Could Help ID Alzheimer's Risk in Young Adults
Risk Score Could Help ID Alzheimer's Risk in Young Adults

THURSDAY, July 7, 2016 (HealthDay News) -- A genetic test may one day be able to predict the risk for Alzheimer's disease (AD) in young adults, according to a study published online July 6 in Neurology.

Elizabeth C. Mormino, Ph.D., of Massachusetts General Hospital, and colleagues calculated a genetic risk score based on whether a person had several high-risk gene mutations. The participants, average age 75, included 166 people with dementia and more than 1,000 people without dementia. In addition, Mormino's team looked for markers of AD, including cognitive decline, clinical progression, and the size of the hippocampus. They also looked at links between the risk score and hippocampus size in more than 1,300 healthy 18- to 35-year-olds.

The investigators found that among older people without dementia, a higher genetic risk score was associated with worse memory, clinical progression, and a smaller hippocampus. High scores were also associated with AD-like levels of β-amyloid burden as measured with florbetapir PET. Among the younger participants, a high risk score was linked to a smaller hippocampus.

"The influence of this genetic risk may begin in early life and make an individual more susceptible to cognitive impairment in late life," the authors write. "Future refinement of polygenic risk scores may help identify individuals at risk for AD dementia."

Several authors disclosed financial ties to pharmaceutical companies.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Many Health Care Providers Work While Sick

Many Health Care Providers Work While Sick

Pharmacists and physicians have the highest frequency of working with influenza-like illness

Simple Checklist Can Identify Useful Clinical Practice Guidelines

Simple Checklist Can Identify Useful Clinical Practice Guidelines

Eight-item tool developed for clinicians to identify trustworthy, useful, and relevant guidelines

is free, fast, and customized just for you!

Already a member?

Sign In Now »