Risk of Febrile Seizures Up With Vaccine Combos

Share this content:
Risk of Febrile Seizures Up With Vaccine Combos
Risk of Febrile Seizures Up With Vaccine Combos

MONDAY, June 6, 2016 (HealthDay News) -- Concomitant administration of inactivated influenza vaccine (IIV3) and pneumococcal conjugate vaccine (PCV) or diphtheria-tetanus-acellular-pertussis (DTaP)-containing vaccine is associated with an increased risk of febrile seizures (FS), according to a study published online June 6 in Pediatrics.

Jonathan Duffy, M.D., M.P.H., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues examined the risk of FS at zero to one day after vaccination for all routinely recommended vaccinations among children aged 6 through 23 months. A population-based self-controlled risk interval analysis was used, with a control interval of 14 to 20 days after vaccination. The authors controlled for receipt of concomitant vaccines using multivariable regression.

The researchers observed an independent FS risk with PCV 7-valent only (incidence rate ratio [IRR], 1.98; 95 percent confidence interval [CI], 1.00 to 3.91). There was no independent risk for IIV3 (IRR, 0.46; 95 percent CI, 0.21 to 1.02); the risk was increased with administration of IIV3 together with PCV (IRR, 3.50; 95 percent CI, 1.13 to 10.85) or a DTaP-containing vaccine (IRR, 3.50; 95 percent CI, 1.52 to 8.07). Compared with administration on separate days, the maximum estimated absolute excess risk due to concomitant administration of IIV3, PCV, and DTaP-containing vaccines was 30 FS per 100,000 persons vaccinated.

"The administration of IIV3 on the same day as either PCV or a DTaP-containing vaccine was associated with a greater risk of FS than when IIV3 was given on a separate day," the authors write. "The absolute risk of post-vaccination FS with these vaccine combinations was small."

Two authors disclosed financial ties to the biopharmaceutical industry.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »