Review Supports LMWH for Cancer-Linked Incidental PE

This article originally appeared here.
Share this content:
Review Supports LMWH for Cancer-Linked Incidental PE
Review Supports LMWH for Cancer-Linked Incidental PE

THURSDAY, Oct. 29, 2015 (HealthDay News) -- Cancer-associated incidental pulmonary embolism (IPE) should be treated with low molecular weight heparins (LMWHs), according to a review published online Oct. 15 in the Journal of Thrombosis and Haemostasis.

Tom van der Hulle, M.D., from Leiden University Medical Center in the Netherlands, and colleagues conducted a systematic literature review on cancer-associated IPE management. They pooled data on incidence rates of symptomatic recurrent VTE, major hemorrhage, and mortality during a six-month follow-up of 926 cancer patients with IPE from 11 cohorts.

The researchers found that the weighted pooled six-month risks were 5.8, 4.7, and 37 percent for recurrent VTE, major hemorrhage, and mortality, respectively. The risk of VTE recurrence was comparable under LMWHs and vitamin-K antagonists (VKAs) (6.2 versus 6.4 percent; hazard ratio [HR], 0.9; 95 percent confidence interval [CI], 0.3 to 3.1), compared with 12 percent in untreated patients (HR, 2.6; 95 percent CI, 0.91 to 7.3). Major hemorrhage risk was higher under VKA than LMWH (13 versus 3.9 percent; HR, 3.9; 95 percent CI, 1.6 to 10). In patients with subsegmental IPE and those with a more proximally localized IPE, the VTE recurrence risk was comparable (HR, 1.1; 95 percent CI, 0.50 to 2.4).

"These results support the current recommendation to anticoagulate cancer-associated IPE with LMWH and argue against different management of subsegmental IPE," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »