Review of Evidence Confirms Efficacy of Statin Therapy

Share this content:
Review of Evidence Confirms Efficacy of Statin Therapy
Review of Evidence Confirms Efficacy of Statin Therapy

MONDAY, Sept. 12, 2016 (HealthDay News) -- Statins are efficacious and safe for reducing the risk of vascular events, according to a review published online Sept. 8 in The Lancet.

Rory Collins, M.B.B.S., from the University of Oxford in the United Kingdom, and colleagues examined the evidence from randomized controlled trials relating to the efficacy and safety of statin therapy.

The researchers found that based on evidence from randomized trials, statin therapy reduced the risk of major vascular events by about one-quarter for each mmol/L reduction in low-density lipoprotein (LDL) cholesterol during each year of use (after the first). The absolute benefit was dependent on the risk of occlusive vascular events and the reduction in LDL cholesterol for individual patients. The benefit of statin therapy on reducing vascular disease risk continued for each year of use, with larger absolute benefits for prolonged therapy; these benefits persisted in the long term.

"Whereas the rare cases of myopathy and any muscle-related symptoms that are attributed to statin therapy generally resolve rapidly when treatment is stopped, the heart attacks or strokes that may occur if statin therapy is stopped unnecessarily can be devastating," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »