Review: Noncomplete Mesorectal Excision Up With Laparoscopy

Share this content:
Review: Noncomplete Mesorectal Excision Up With Laparoscopy
Review: Noncomplete Mesorectal Excision Up With Laparoscopy

FRIDAY, Feb. 10, 2017 (HealthDay News) -- Patients undergoing laparoscopic rectal resection (LRR) have increased risk for noncomplete mesorectal excision versus those undergoing open rectal resection (ORR), according to a review and meta-analysis published online Feb. 8 in JAMA Surgery.

Aleix Martínez-Pérez, M.D., from the Henri Mondor University Hospital in Paris, and colleagues conducted a systematic review of randomized clinical trials (RCTs) that compared LRR with ORR for histologically proven rectal cancer in adult patients. Data were included for 14 RCTs with 4,034 unique patients.

Of the 2,989 patients undergoing rectal resection, the researchers identified a positive circumferential resection margin in 7.9 and 6.1 percent of the 1,697 and 1,292 patients undergoing LRR and ORR, respectively (risk ratio, 1.17; 95 percent confidence interval, 0.89 to 1.53; P = 0.26) in nine studies. In five studies, a noncomplete (nearly complete and incomplete) mesorectal excision occurred in 13.2 and 10.4 percent of 1,354 patients undergoing LRR and the 998 patients undergoing ORR, respectively (risk ratio, 1.31; 95 percent confidence interval, 1.05 to 1.64; P = 0.02). There was no significant difference between LRR and ORR in the distal resection margin involvement, the mean number of lymph nodes retrieved, the mean distance to the distal margin, and the mean distance to radial margins.

"These findings question the oncologic safety of laparoscopy for the treatment of rectal cancer," the authors write.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Better Stem Cell Tx Outcomes for Younger MS Patients

Better Stem Cell Tx Outcomes for Younger MS ...

Results support additional trials of autologous hematopoietic stem cell transplantation

OD Risk Up in Children Whose Mothers Are Prescribed Opioids

OD Risk Up in Children Whose Mothers Are ...

Second study finds opioids stored unsafely in many households with children

AAP Urges Doctors Not to Punish Pregnant Women for Opioid Use

AAP Urges Doctors Not to Punish Pregnant Women ...

Group says better prevention and treatment, not jail time, would stem surge in drug-addicted newborns

is free, fast, and customized just for you!

Already a member?

Sign In Now »