Review Links Albuminuria to Cognitive Impairment, Dementia

Share this content:
Review Links Albuminuria to Cognitive Impairment, Dementia
Review Links Albuminuria to Cognitive Impairment, Dementia

MONDAY, Feb. 13, 2017 (HealthDay News) -- Albuminuria is associated with cognitive impairment, dementia, and cognitive decline, according to a review published online Feb. 2 in the Journal of the American Geriatrics Society.

Marios K. Georgakis, M.D., from the University of Athens in Greece, and colleagues conducted a systematic review to examine the correlation between albuminuria and cognitive impairment, dementia, and cognitive function. Data were included for 32 eligible studies.

The researchers found that albuminuria correlated with cognitive impairment, dementia, clinical Alzheimer's disease, and vascular dementia (odds ratios, 1.35, 1.35, 1.37, and 1.96, respectively). The significant effect persisted in longitudinal, population-based, and high-quality studies. In time-to-event analysis of prospective studies involving individuals without dementia at baseline, there was a significant association with incident dementia (risk ratio, 1.52). Subjects with albuminuria had worse global cognitive performance and accelerated cognitive decline (Hedge's g, −0.13 and −0.20, respectively); they also scored lower in executive function, processing speed, verbal fluency, and verbal memory.

"The stronger effects for vascular dementia and cognitive performance in domains primarily affected by microvascular disease support that the association could be mediated by shared microvascular pathology in the kidney and the brain," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

FDA Warns of Possible Heart Risks Linked to Clarithromycin

FDA Warns of Possible Heart Risks Linked to ...

Agency advising doctors to consider prescribing other antibiotics to patients with coronary heart disease

Artificial Intelligence May Help Prevent Physician Burnout

Artificial Intelligence May Help Prevent Physician Burnout

Many potential uses for AI, including improving searches and documentation, selecting treatment

Benzodiazepine Use Declining in Older Adults

Benzodiazepine Use Declining in Older Adults

Findings based on assessment of incidence, prevalence of use in three countries from 2010-2016

is free, fast, and customized just for you!

Already a member?

Sign In Now »