Review: Dabigatran Comparable to Warfarin for Nonvalvular A-Fib

This article originally appeared here.
Share this content:
Review: Dabigatran Comparable to Warfarin for Nonvalvular A-Fib
Review: Dabigatran Comparable to Warfarin for Nonvalvular A-Fib

WEDNESDAY, Jan. 27, 2016 (HealthDay News) -- For patients with nonvalvular atrial fibrillation, dabigatran 150 mg is comparable to warfarin for preventing ischemic stroke, and correlates with lower risk of intracranial bleeding but higher risk of gastrointestinal bleeding, according to a review published online Jan. 26 in Circulation: Cardiovascular Quality and Outcomes.

Robert J. Romanelli, Ph.D., M.P.H., from the Palo Alto Medical Foundation Research Institute in California, and colleagues conducted a systematic review to examine the real-world evidence for the comparative effectiveness and safety of dabigatran versus warfarin in the treatment of nonvalvular atrial fibrillation. Data were included for seven retrospective cohort studies, with 348,750 patients followed for a mean of 2.2 years.

The researchers found that dabigatran 150 mg was not superior to warfarin for preventing stroke in pooled analyses (hazard ratio, 0.92; 95 percent confidence interval, 0.84 to 1.01), but was associated with a significantly lower risk of intracranial bleeding (hazard ratio, 0.44; 95 percent confidence interval, 0.34 to 0.59). Compared with warfarin, dabigatran 150 mg correlated with a significantly greater risk of gastrointestinal bleeding (1.23; 95 percent confidence interval, 1.01 to 1.50), which was potentiated in studies of older versus younger populations (median/mean age, ≥75 versus <75 years: β = 1.53; 95 percent confidence interval, 1.10 to 2.14).

"In real-world clinical practice, dabigatran is comparable with warfarin in preventing ischemic stroke among patients with nonvalvular atrial fibrillation," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »