Retinoblastoma Mortality Up With Eye-Preserving Radiotherapy

This article originally appeared here.
Share this content:
Retinoblastoma Mortality Up With Eye-Preserving Radiotherapy
Retinoblastoma Mortality Up With Eye-Preserving Radiotherapy

FRIDAY, July 8, 2016 (HealthDay News) -- Short-term survival of heritable retinoblastoma is high, but long-term mortality remains a challenge, according to a study published online July 5 in the Journal of Clinical Oncology.

Petra Temming, M.D., from University Hospital Essen in Germany, and colleagues analyzed data from 633 German children treated at the national reference center for heritable retinoblastoma in order to identify the impact of eye-preserving therapy on long-term survival.

The researchers found that the five-year overall survival of children diagnosed in Germany with heritable retinoblastoma from 1940 to 2008 was 93.2 percent. Long-term mortality was increased in those with heritable disease versus those with nonheritable disease. Overall survival correlated with tumor staging, and 92 percent of patients were diagnosed with a favorable tumor stage. While five-year overall survival in patients with stage 0 or 1 was 97.4 percent, only 79.5 percent of these patients survived 40 years after diagnosis. In children treated with eye-preserving radiotherapy, long-term overall survival was reduced versus those treated with enucleation alone. Adding chemotherapy aggravated this effect.

"The benefits of preserving vision must be balanced with the impact of eye-preserving treatments on long-term survival in heritable retinoblastoma, and the genetic background of the patient influences choice of eye-preserving treatment," conclude the authors.

Three authors disclosed financial ties to pharmaceutical companies.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »