Resveratrol Reduces Ovarian, Adrenal Androgens in PCOS

This article originally appeared here.
Share this content:
Resveratrol Reduces Ovarian, Adrenal Androgens in PCOS
Resveratrol Reduces Ovarian, Adrenal Androgens in PCOS

THURSDAY, Oct. 20, 2016 (HealthDay News) -- For patients with polycystic ovary syndrome (PCOS), resveratrol is associated with significant reductions in ovarian and adrenal androgens, according to a study published online Oct. 18 in the Journal of Clinical Endocrinology & Metabolism.

Beata Banaszewska, M.D., Ph.D., from the Poznan University of Medical Sciences in Poland, and colleagues evaluated endocrine and metabolic effects of resveratrol on PCOS in a randomized placebo-controlled trial conducted over a three-month period. Thirty-four patients were enrolled in the trial and 30 completed the trial.

The researchers observed a significant 23.1 percent decrease in total testosterone with resveratrol (P = 0.1). Resveratrol also induced a 22.2 percent decrease in dehydroepiandrosterone sulfate, a 31.8 percent decrease in fasting insulin level, and a 66.3 percent increase in the Insulin Sensitivity Index (P = 0.01, 0.007, and 0.04, respectively). There were no significant alterations in the levels of gonadotropins, lipid profiles, and markers of inflammation and endothelial function.

"Resveratrol significantly reduced ovarian and adrenal androgens," the authors write. "This effect may be, at least in part, related to an improvement of insulin sensitivity and a decline of insulin level."

RevGenetics provided resveratrol for this study. The Adamed Group partially supported the study and produced the placebo pills.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Adding HIPEC to Cytoreductive Surgery Beneficial in Ovarian CA

Adding HIPEC to Cytoreductive Surgery Beneficial in Ovarian ...

Longer survival with hyperthermic intraperitoneal chemotherapy in stage III epithelial ovarian cancer

Chaplains Effective in Facilitating Advance Care Planning

Chaplains Effective in Facilitating Advance Care Planning

80 percent of patients who met chaplains in medical practice completed or provided advance directive

Alzheimer's Disease Variants Linked to Brain Amyloidosis

Alzheimer's Disease Variants Linked to Brain Amyloidosis

Significant correlations found for adenosine triphosphate-binding cassette subfamily A member

is free, fast, and customized just for you!

Already a member?

Sign In Now »