Resting-State Connectivity Predicts Psychotherapy Response

This article originally appeared here.
Share this content:
Resting-State Connectivity Predicts Psychotherapy Response
Resting-State Connectivity Predicts Psychotherapy Response

MONDAY, Feb. 9, 2015 (HealthDay News) -- Resting-state functional brain connectivity magnetic resonance imaging (rs-fcMRI) can predict response to psychotherapy in major depressive disorder (MDD), according to a study published online Feb. 4 in Neuropsychopharmacology.

Andrew Crowther, from the University of North Carolina at Chapel Hill, and colleagues examined whether rs-fcMRI predicted response to an empirically validated psychotherapy modality (Behavioral Activation Treatment for Depression). rs-fcMRI scans were performed on 23 unmedicated outpatients with MDD and 20 matched nondepressed controls. The MDD group subsequently received an average of 12 psychotherapy sessions.

The researchers observed a mean change in Beck Depression Inventory-II scores of 12.04 points, which was clinically meaningful. The MDD group was characterized at baseline by relative hyperconnectivity of multiple regions with precuneus, anterior insula, dorsal anterior cingulate cortex (dACC), and left dorsolateral prefrontal cortex seeds, and by relative hypoconnectivity with intraparietal sulcus, anterior insula, and dACC seeds. The magnitude of pretreatment MDD symptoms was predicted by connectivity of the precuneus with the left middle temporal gyrus and connectivity of the dACC with the parahippocampal gyrus. Pretreatment connectivity of the right insula with the right middle temporal gyrus and the left intraparietal sulcus with the orbital frontal cortex predicted response to psychotherapy in the MDD group.

"These results add to the nascent body of literature investigating pretreatment rs-fcMRI predictors of antidepressant treatment response and is the first study to examine rs-fcMRI predictors of response to psychotherapy," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

Congress Approves Bill Expanding Private Care for VA Patients

Congress Approves Bill Expanding Private Care for VA ...

New bill would open up access to private doctors for veterans

AAP Recommending Injectable Flu Shot for 2018-19 Flu Season

AAP Recommending Injectable Flu Shot for 2018-19 Flu ...

Children should receive injectable vaccine, which has been shown to be more consistently effective

Neurologists Identify New Type of Vertigo

Neurologists Identify New Type of Vertigo

Long-term prognosis favorable, with improvement of symptoms in more than half of patients