Researchers ID Three New Glaucoma-Related Genes

This article originally appeared here.
Share this content:
Researchers ID Three New Glaucoma-Related Genes
Researchers ID Three New Glaucoma-Related Genes

TUESDAY, Jan. 12, 2016 (HealthDay News) -- Three newly identified genes associated with primary open angle glaucoma bring the total number of such genes to 15, according to a study published online Jan. 11 in Nature Genetics.

In the new study, which was funded by the U.S. National Eye Institute (NEI), the researchers pinpointed the three new genes linked with open angle glaucoma by comparing the DNA of 3,853 patients of European ancestry with the disease, and 33,480 people without it. The investigators also analyzed additional data from Europe, Australia, New Zealand, and Singapore.

Certain variations in the genes FOXC1, TXNRD2, and ATXN2 are associated with primary open angle glaucoma, study author Janey Wiggs, M.D., Ph.D., said in an NEI news release. Wiggs is the associate director of the Ocular Genomics Institute at the Massachusetts Eye and Ear Infirmary of Harvard Medical School in Boston. All three genes are expressed in the eye, and TXNRD2 and ATXN2 are active in the optic nerve. Previous research linked FOXC1 and glaucoma, but only in rare cases of severe early-onset glaucoma, the news release said.

"This unprecedented analysis provides the most comprehensive genetic profile of glaucoma to date," Paul Sieving, M.D., Ph.D., director of the NEI, said in the news release. "These findings open avenues for the pursuit of new strategies to screen for, prevent, and treat glaucoma."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »