Research Offers Insight Into Zika Virus Transmission to Placenta

Share this content:
Research Offers Insight Into Zika Virus Transmission to Placenta
Research Offers Insight Into Zika Virus Transmission to Placenta

FRIDAY, Aug. 19, 2016 (HealthDay News) -- Primary human placental macrophages, known as Hofbauer cells, and placental villous fibroblasts are susceptible to infection by Zika virus, according to research published online Aug. 18 in JCI Insight.

Kellie Ann Jurado, Ph.D., from the Yale University School of Medicine in New Haven, Conn., and colleagues examined potential mechanisms involved in Zika virus crossing the placental barrier.

The researchers demonstrated permissive Zika virus infection of Hofbauer cells and placental villous fibroblasts. Using term placental villous explants, they demonstrated Zika virus infection of Hofbauer cells within the context of the tissue ex vivo. The putative migratory activities of Hofbauer cells may aid in dissemination of Zika to the fetal brain, in addition to amplifying infectious virus within a usually inaccessible area.

"Understanding the susceptibility of placenta-specific cell types will aid future work around and understanding of Zika virus-associated pregnancy complications," the authors write.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

Aspirin, Rivaroxaban Similar After Total Hip, Knee Arthroplasty

Aspirin, Rivaroxaban Similar After Total Hip, Knee Arthroplasty

Extended prophylaxis with aspirin no different from rivaroxaban for preventing venous thromboembolism

Odds of ARDS Up After Cardiac Surgery During Flu Season

Odds of ARDS Up After Cardiac Surgery During ...

Cardiac surgery during flu season is independent risk factor for acute respiratory distress syndrome

In A-Fib Patients, Stroke Risk Higher for Blacks Than Whites

In A-Fib Patients, Stroke Risk Higher for Blacks ...

Higher risk of ischemic stroke seen before, after atrial fibrillation diagnosis compared with whites

is free, fast, and customized just for you!

Already a member?

Sign In Now »