Research Offers Insight Into Zika Virus Transmission to Placenta

Share this content:
Research Offers Insight Into Zika Virus Transmission to Placenta
Research Offers Insight Into Zika Virus Transmission to Placenta

FRIDAY, Aug. 19, 2016 (HealthDay News) -- Primary human placental macrophages, known as Hofbauer cells, and placental villous fibroblasts are susceptible to infection by Zika virus, according to research published online Aug. 18 in JCI Insight.

Kellie Ann Jurado, Ph.D., from the Yale University School of Medicine in New Haven, Conn., and colleagues examined potential mechanisms involved in Zika virus crossing the placental barrier.

The researchers demonstrated permissive Zika virus infection of Hofbauer cells and placental villous fibroblasts. Using term placental villous explants, they demonstrated Zika virus infection of Hofbauer cells within the context of the tissue ex vivo. The putative migratory activities of Hofbauer cells may aid in dissemination of Zika to the fetal brain, in addition to amplifying infectious virus within a usually inaccessible area.

"Understanding the susceptibility of placenta-specific cell types will aid future work around and understanding of Zika virus-associated pregnancy complications," the authors write.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Illicit Marijuana Use Up in States With Legal Medical Use

Illicit Marijuana Use Up in States With Legal ...

Cannabis use disorder is also rising faster in states with legalization laws

Chromosome Instability Test Prognostic in NSCLC

Chromosome Instability Test Prognostic in NSCLC

Chromosome instability associated with higher risk of relapse, death within 2 years

CDC: Opioid-Related Mortality Rate Might Be Underestimated

CDC: Opioid-Related Mortality Rate Might Be Underestimated

Death certificates from drug-linked infections may not label opioids as possible cause

is free, fast, and customized just for you!

Already a member?

Sign In Now »