Research Offers Insight Into Zika Virus Transmission to Placenta

Share this content:
Research Offers Insight Into Zika Virus Transmission to Placenta
Research Offers Insight Into Zika Virus Transmission to Placenta

FRIDAY, Aug. 19, 2016 (HealthDay News) -- Primary human placental macrophages, known as Hofbauer cells, and placental villous fibroblasts are susceptible to infection by Zika virus, according to research published online Aug. 18 in JCI Insight.

Kellie Ann Jurado, Ph.D., from the Yale University School of Medicine in New Haven, Conn., and colleagues examined potential mechanisms involved in Zika virus crossing the placental barrier.

The researchers demonstrated permissive Zika virus infection of Hofbauer cells and placental villous fibroblasts. Using term placental villous explants, they demonstrated Zika virus infection of Hofbauer cells within the context of the tissue ex vivo. The putative migratory activities of Hofbauer cells may aid in dissemination of Zika to the fetal brain, in addition to amplifying infectious virus within a usually inaccessible area.

"Understanding the susceptibility of placenta-specific cell types will aid future work around and understanding of Zika virus-associated pregnancy complications," the authors write.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »