Research for Post-Craniotomy Analgesia Uneven in Quality

Share this content:
Research for Post-Craniotomy Analgesia Uneven in Quality
Research for Post-Craniotomy Analgesia Uneven in Quality

FRIDAY, Dec. 23, 2016 (HealthDay News) -- Studies reporting pharmacological and adjuvant analgesic modalities for post-craniotomy pain control have significant divergence in their research methods, according to a review published online Dec. 20 in Pain Practice.

Georgia G. Tsaousi, M.D., Ph.D., from Aristotle University of Thessaloniki in Greece, and colleagues conducted a systematic review of the literature to report current clinical evidence relating to pharmacological and adjuvant analgesic modalities for post-craniotomy pain control. Nineteen randomized controlled trials (RCTs) with 1,805 patients were included.

The researchers found that quality of research methods was moderate to good for most of the studies. Fourteen RCTs assessed systemic pharmacological intervention. Superior pain relief was provided by opioids (five RCTs), with no significant side effects, but the study quality was low. Adequate craniotomy pain control was presented by diclofenac (three RCTs), without adverse effects, but there was no support for parecoxib. Adequate transitional analgesia was provided by dexmedetomidine (three RCTs), but further research is needed. Very limited data were available on the analgesic efficacy of gabapentin, pregabalin, and intravenous lidocaine (one RCT each). In the early postoperative period, scalp infiltration/block provided adequate analgesia (three RCTs), while more studies are needed to verify the analgesic benefit from nonpharmacological interventions (two RCTs).

"No definite recommendations can be made based on this systematic review of pharmacological interventions following craniotomy due to significant divergence in the methodology of available studies," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

ASA: Class-Specific Link Between Periodontal Disease and Stroke

ASA: Class-Specific Link Between Periodontal Disease and Stroke

Link strongest for thrombotic strokes, cardioembolic strokes

ASA: Not Enough Stroke Patients Being Treated With tPA

ASA: Not Enough Stroke Patients Being Treated With ...

Minorities, women, seniors on Medicare, rural residents less likely to be diagnosed in time for tPA

Cytomegalovirus May Up Risk of Diabetes, CVD in Some Women

Cytomegalovirus May Up Risk of Diabetes, CVD in ...

Conversely, for women with extreme obesity, CMV may offer protection against CVD, DM

is free, fast, and customized just for you!

Already a member?

Sign In Now »