Repeated Antibiotic Use in Children May Contribute to T1DM

Share this content:
Repeated Antibiotic Use in Children May Contribute to T1DM
Repeated Antibiotic Use in Children May Contribute to T1DM

TUESDAY, Aug. 23, 2016 (HealthDay News) -- Repeated treatments with antibiotics have been linked to the development of type 1 diabetes in mice, according to a study published online Aug. 22 in Nature Microbiology.

Martin Blaser, M.D., a professor of translational medicine and microbiology at the NYU Langone Medical Center in New York City, and colleagues looked at the effects of antibiotics on non-obese mice that were susceptible to type 1 diabetes. The team used very young mice, similar in age to a 6- month to 1-year old child. The mice were given pulsed antibiotic therapy (three doses at different time periods), a continuous but very low dose of antibiotics, or no antibiotics.

Mice exposed to the pulsed therapy were twice as likely to develop type 1 diabetes as mice that got no antibiotics. Blaser told HealthDay that antibiotics led to a change in the microbiome in the gut. Those changes resulted in other changes, including alterations in T cells. That, in turn, led to increased inflammation in the insulin-producing islet cells of the pancreas, he said. The researchers also transferred some of the changed gut microbiota from the antibiotic-exposed mice to two other groups of mice. This increased the risk of type 1 diabetes in one group, but not the other.

"These findings show that early-life antibiotic treatments alter the gut microbiota and its metabolic capacities, intestinal gene expression and T-cell populations, accelerating type 1 diabetes onset in non-obese diabetic mice," the authors conclude.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

AAN: Alpha-Synuclein Levels in Tears May Help ID Parkinson's

AAN: Alpha-Synuclein Levels in Tears May Help ID ...

PD patients have significantly decreased total alpha-synuclein in tears compared with healthy controls

Younger Onset of T2DM Linked to Increased Mortality Risk

Younger Onset of T2DM Linked to Increased Mortality ...

Earlier diagnosis of T2DM tied to increased mortality, mainly driven by cardiovascular disease mortality

Menopausal Hormone Therapy Tied to Less Pronounced Kyphosis

Menopausal Hormone Therapy Tied to Less Pronounced Kyphosis

Continuous and remote past HT users had less kyphosis in minimally-, fully-adjusted models

is free, fast, and customized just for you!

Already a member?

Sign In Now »