Renal Function Decline Linked to Major Adverse CV Events

Share this content:
Renal Function Decline Linked to Major Adverse CV Events
Renal Function Decline Linked to Major Adverse CV Events

THURSDAY, May 26, 2016 (HealthDay News) -- The risk of major adverse cardiovascular events (MACE) is increased with renal function decline, according to a study published online May 23 in Diabetes Care.

Stéphanie Ragot, Pharm.D., Ph.D., from INSERM CIC 1402 in Poitiers, France, and colleagues examined the correlation between renal function trajectories and the occurrence of a cardiovascular (CV) event in patients with type 2 diabetes from a discovery cohort (1,040 participants) and replication cohort.

The researchers found that over 6.3 years of follow-up there was an annual estimated glomerular filtration rate (eGFR) decline and an annual serum creatinine (SCr) increase that was significantly greater in patients with versus those without MACE (P < 0.0001 for both). Patients with MACE had significantly steeper median annual individual slopes; patients with rapid decline in eGFR had adjusted risk of MACE that was 4.11 times higher. Significant additive information to help explain the occurrence of MACE for both SCr and eGFR was seen with consideration of renal function trajectories. Results were confirmed in the replication cohort.

"Renal function decline was associated with a higher risk of MACE," the authors write. "The pattern of renal function decline, beyond baseline kidney function, is an independent factor of CV risk."

Several authors disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

ASTRO: No Survival Benefit for Adding EBT to Brachytherapy

ASTRO: No Survival Benefit for Adding EBT to ...

Addition of external beam therapy doesn't improve five-year progression-free survival in prostate cancer

ASTRO: Fewer Side Effects With IMRT in Cervical, Endometrial CA

ASTRO: Fewer Side Effects With IMRT in Cervical, ...

Patients in conventional radiotherapy arm had more high-level adverse events than those in IMRT arm

Many Doctors Reluctant to Reveal Mental Health Issues

Many Doctors Reluctant to Reveal Mental Health Issues

Perceived stigma, fear of career repercussions hinder treatment, study suggests

is free, fast, and customized just for you!

Already a member?

Sign In Now »