Remission Up With T Cell Therapy for Non-Hodgkin's Lymphoma

Share this content:
Remission Up With T Cell Therapy for Non-Hodgkin's Lymphoma
Remission Up With T Cell Therapy for Non-Hodgkin's Lymphoma

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Immunotherapy with CD19 chimeric antigen receptor (CAR)-modified T cells in a defined CD4+/CD8+ ratio can lead to improved disease response and overall and progression-free survival, according to a study published in the Sept. 7 issue of Science Translational Medicine.

Cameron Turtle, Ph.D., an immunotherapy researcher with the Fred Hutchinson Cancer Research Center in Seattle, and colleagues manufactured CD19 CAR-T cells from defined T cell subsets. The therapy was administered in a 1:1 CD4+/CD8+ ratio of CAR-T cells to 32 adults with relapsed and/or refractory B cell non-Hodgkin's lymphoma after cyclophosphamide (Cy)-based lymphodepletion chemotherapy with or without fludarabine (Flu).

The researchers found that patients who underwent Cy/Flu lymphodepletion had increased CAR-T cell expansion and persistence, and higher response rates than patients who received Cy-based lymphodepletion without Flu (50 percent complete remission [CR], 72 percent overall response rate [ORR] versus 8 percent CR, 50 percent ORR). Serum biomarkers one day after CAR-T cell infusion correlated with severe cytokine release syndrome and grade ≥3 neurotoxicity, which were observed in 13 and 28 percent of all patients, respectively.

"Immunotherapy with CD19 CAR-T cells in a defined CD4+/CD8+ ratio allowed identification of correlative factors for CAR-T cell expansion, persistence, and toxicity, and facilitated optimization of lymphodepletion that improved disease response and overall and progression-free survival," the authors write.

Several authors disclosed financial ties to Juno Therapeutics, which contributed funding to the study.

Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

U.S. High School Students Report Sport-Linked Concussion

U.S. High School Students Report Sport-Linked Concussion

Overall, 15.1 percent of students reported having at least one concussion in the previous 12 months

Corneal Abnormalities Seen With Down Syndrome

Corneal Abnormalities Seen With Down Syndrome

More than 70 percent of patients in Down syndrome group had traits compatible with keratoconus

Many Childhood CA Survivors Not Concerned About Future Health

Many Childhood CA Survivors Not Concerned About Future ...

Even among those exposed to high radiation doses, one-third not concerned about developing cancer

is free, fast, and customized just for you!




Already a member?

Sign In Now »