Reduced eGFR, Increased UACR Linked to Incident A-Fib

This article originally appeared here.
Share this content:
Reduced eGFR, Increased UACR Linked to Incident A-Fib
Reduced eGFR, Increased UACR Linked to Incident A-Fib

FRIDAY, Aug. 11, 2017 (HealthDay News) -- Reduced estimated glomerular filtration rate (eGFR) and elevated urine albumin-to-creatinine ratio (UACR) are associated with increased risk of incident atrial fibrillation (AF), according to research published online Aug. 10 in the Clinical Journal of the American Society of Nephrology.

Nisha Bansal, M.D., from the University of Washington in Seattle, and colleagues conducted a meta-analysis of three prospective cohorts (16,769 participants) to examine the correlation of eGFR and UACR with the risk of incident AF.

The researchers found that across categories of decreasing eGFR, there was a step-wise increase in the adjusted risk of incident AF, with hazard ratios of 1.00, 1.09 (95 percent confidence interval [CI], 0.97 to 1.24), 1.17 (95 percent CI, 1.00 to 1.38), 1.59 (95 percent CI, 1.28 to 1.98), and 2.03 (95 percent CI, 1.40 to 2.96), for eGFR >90 (reference), 60 to 89, 45 to 59, 30 to 44, and <30 ml/min/1.73 m², respectively. Across categories of increasing UACR there was a step-wise increase in the adjusted risk of incident AF, with hazard ratios of 1.00, 1.04 (95 percent CI, 0.83 to 1.30), 1.47 (95 percent CI, 1.20 to 1.79), and 1.76 (95 percent CI, 1.18 to 2.62), respectively, for UACR <15 (reference), 15 to 29, 30 to 299, and ≥300 mg/g, respectively.

"These data highlight the need for further studies to examine the mechanistic link between kidney disease and AF," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Even Overdose Doesn't Stop Opioid Prescribing

Even Overdose Doesn't Stop Opioid Prescribing

Few receive medication-assisted treatment after hospital discharge, researchers find

NT-ProBNP-Guided Treatment No Benefit in High-Risk HFrEF

NT-ProBNP-Guided Treatment No Benefit in High-Risk HFrEF

No improvement in clinical outcomes versus usual care in heart failure and reduced ejection fraction

Oral Corticosteroids No Benefit for LRI in Non-Asthmatic Adults

Oral Corticosteroids No Benefit for LRI in Non-Asthmatic ...

No decrease in cough duration, severity for adults without asthma with lower respiratory tract symptom

is free, fast, and customized just for you!

Already a member?

Sign In Now »