Recombinant tPA Safe for Patients With Wake-Up Stroke

This article originally appeared here.
Share this content:
Recombinant tPA Safe for Patients With Wake-Up Stroke
Recombinant tPA Safe for Patients With Wake-Up Stroke

FRIDAY, June 17, 2016 (HealthDay News) -- For patients with wake-up stroke (WUS), treatment with recombinant tissue plasminogen activator (rtPA) seems safe, according to a study published online June 6 in the Annals of Neurology.

Andrew D. Barreto, M.D., from the University of Texas Health Science Center at Houston, and colleagues examined the safety of rtPA in a prospective study involving 40 patients with WUS with disabling deficits, selected only on the appearance of non-contrast computed tomography (CT). Patients were treated with standard-dose intravenous rtPA within three hours of awakening. Four of the patients were subsequently determined to be mimics.

Patients received thrombolysis at a mean time of 10.3 ± 2.6 hours from last seen normal and 2.6 ± 0.6 hours from awakening with deficits. The researchers found that there were no cases of symptomatic intracerebral hemorrhage or parenchymal hematomas. Overall, 52.6 percent of the 38 patients who were followed achieved excellent recovery, with modified Rankin scale scores of 0 or 1.

"Intravenous thrombolysis was safe in this prospective WUS study of patients selected by non-contrast CT," the authors write. "A randomized effectiveness trial appears feasible using a similar, pragmatic design."

Several authors disclosed financial ties to Genentech, which partially funded the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

CDC Concerned About Falling Flu Vaccination Rates

CDC Concerned About Falling Flu Vaccination Rates

Decline among vulnerable older adults is of particular concern

One in Five With Non-Valvular A-Fib Receiving Digoxin

One in Five With Non-Valvular A-Fib Receiving Digoxin

Indication for digoxin use was considered inappropriate in 59.8 percent in Turkish cohort

Rapid, Successful Response to ART for Many Patients With HIV

Rapid, Successful Response to ART for Many Patients ...

Factors associated with virological success include having undetectable viral load, use of three drugs

is free, fast, and customized just for you!

Already a member?

Sign In Now »