Ranolazine Added to Glimepiride Cuts HbA1c in T2DM

This article originally appeared here.
Share this content:
Ranolazine Added to Glimepiride Cuts HbA1c in T2DM
Ranolazine Added to Glimepiride Cuts HbA1c in T2DM

MONDAY, Jan. 18, 2016 (HealthDay News) -- For patients with type 2 diabetes on background glimepiride therapy, but not metformin, addition of ranolazine is associated with a significant reduction in hemoglobin A1c (HbA1c), according to research published online Jan. 8 in Diabetes, Obesity and Metabolism.

Jeremy Pettus, M.D., from the University of California, San Diego, and colleagues examined the efficacy of ranolazine for glycemic control in patients with type 2 diabetes on metformin or glimepiride. The authors randomized 431 and 442 patients to ranolazine versus placebo added to glimepiride or metformin background therapy, respectively. To correct for the metformin-ranolazine pharmacokinetic interaction, patients receiving ranolazine added to metformin had their metformin dose halved.

The researchers found that, compared with placebo, the addition of ranolazine to glimepiride was associated with a 0.51 percent decrease from baseline in HbA1c at 12 weeks, and near doubling of the proportion of patients achieving an HbA1c of <7 percent (27.1 versus 14.1 percent; P = 0.001). There was no significant difference in the 24-week HbA1c change from baseline when ranolazine was added to metformin background therapy.

"In conclusion, relative to placebo, ranolazine added to glimepiride reduced HbA1c by 0.51 percent, while combination therapy with metformin did not significantly decrease HbA1c, though this was in the setting of reduced metformin dosing relative to those taking placebo," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Gilead Sciences, which manufactures ranolazine and funded the research.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »