Ramucirumab Shows Promise in Care of Advanced Gastric Cancer

This article originally appeared here.
Share this content:
Ramucirumab Shows Promise in Care of Advanced Gastric Cancer
Ramucirumab Shows Promise in Care of Advanced Gastric Cancer

TUESDAY, Oct. 24, 2017 (HealthDay News) -- Ramucirumab appears to be safe and effective for the treatment of advanced gastric cancer, according to a study published online Sept. 29 in the Journal of Gastroenterology and Hepatology.

Kei Muro, M.D., from Aichi Cancer Center Hospital in Japan, and colleagues conducted subgroup analyses the REGARD and RAINBOW trials. Both were global, phase 3, randomized, double-blind trials of second-line ramucirumab for metastatic gastric or gastroesophageal junction adenocarcinoma.

The researchers found that the hazard ratios (HRs) for overall survival favored treatment with ramucirumab in the REGARD study: ≤45 years (HR, 0.59; 95 percent confidence interval [CI], 0.27 to 1.26); <65 years (HR, 0.8; 95 percent CI, 0.59 to 1.1); ≥65 years (HR, 0.72; 95 percent CI, 0.48 to 1.08), ≥70 years (HR, 0.73; 95 percent CI, 0.44 to 1.23), and ≥75 years (HR, 0.59; 95 percent CI, 0.25 to 1.37). HRs for overall survival also favored treatment with ramucirumab in the RAINBOW study: ≤45 years (HR, 0.56; 95 percent CI, 0.33 to 0.93), <65 years (HR, 0.78; 95 percent CI, 0.63 to 0.97), ≥65 years (HR, 0.88; 95 percent CI, 0.66 to 1.18), and ≥70 years (HR, 0.88; 95 percent CI, 0.6 to 1.28). The exception was elderly individuals ≥75 years in the RAINBOW trial (HR, 0.97; 95 percent CI, 0.47 to 2.01), through there were only 36 patients in this subgroup. Similar results were seen for progression-free survival. Adverse events, including serious ones, were not associated with age.

"Despite some limitations, these exploratory analyses support the use of ramucirumab in advanced gastric cancer, irrespective of age," conclude the authors.

Several authors disclosed financial ties to the pharmaceutical industry, including Eli Lilly and Co., which funded the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Meds for Opioid Use Disorder May Reduce Mortality ...

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

Pharmacists Are Well Placed to Improve Adult Vaccination Rates

Pharmacists Are Well Placed to Improve Adult Vaccination ...

Pharmacies can address cost barriers to vaccination by providing vaccines at lower cost

Single Blood Sample Test May Help ID Undiagnosed Diabetes

Single Blood Sample Test May Help ID Undiagnosed ...

Single-sample confirmatory definition associated with high positive predictive value

is free, fast, and customized just for you!




Already a member?

Sign In Now »