Radiation Tx Impact Varies With Comorbidity in Prostate Cancer

Share this content:
Radiation Tx Impact Varies With Comorbidity in Prostate Cancer
Radiation Tx Impact Varies With Comorbidity in Prostate Cancer

TUESDAY, Sept. 22, 2015 (HealthDay News) -- For men with unfavorable-risk prostate cancer, the impact of radiotherapy (RT) versus RT plus androgen deprivation therapy (ADT) varies with comorbidity, according to a research letter published in the Sept. 22/29 issue of the Journal of the American Medical Association.

Anthony V. D'Amico, M.D., Ph.D., from Brigham and Women's Hospital in Boston, and colleagues used data from a randomized trial to compare overall survival and mortality from prostate cancer, cardiac, or other causes in all men and within subgroups randomized by treatment. Data were included from 206 men with unfavorable-risk prostate cancer who were randomized to receive RT alone or RT and six months of ADT.

The researchers found that 94 percent of men with moderate or severe comorbidity died, compared with 70 percent of those with no or minimal comorbidity. In men with no or minimal comorbidity, RT treatment alone compared with RT and ADT correlated with significantly increased overall mortality (hazard ratio, 1.51) and prostate cancer mortality (hazard ratio, 4.30) in multivariate analyses. For men with moderate or severe comorbidity, RT alone versus RT and ADT correlated with significantly decreased overall mortality and cardiac mortality (hazard ratios, 0.36 and 0.17).

"The association of treatment with RT alone with decreased cardiac and overall mortality in men with moderate or severe comorbidity suggests that administering ADT to treat unfavorable-risk prostate cancer in these men should be carefully considered," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »