Prophylactic Antibiotic Choice Impacts Post-Hysterectomy SSI

Share this content:
Prophylactic Antibiotic Choice Impacts Post-Hysterectomy SSI
Prophylactic Antibiotic Choice Impacts Post-Hysterectomy SSI

FRIDAY, Jan. 15, 2016 (HealthDay News) -- For women undergoing hysterectomy, prophylactic antibiotic choice impacts the risk of surgical site infection rates, according to a study published in the February issue of Obstetrics & Gynecology.

Shitanshu Uppal, M.B.B.S., from the University of Michigan in Ann Arbor, and colleagues conducted a retrospective cohort study of patients in the Michigan Surgical Quality Collaborative undergoing hysterectomy to examine the correlation between prophylactic antibiotic choice and surgical site infection rates. Patients receiving a recommended antibiotic regimen were classified into those receiving β-lactam antibiotics and alternatives to β-lactam antibiotics. Patients receiving nonrecommended antibiotics were classified as those receiving overtreatment (excluded from further analysis) versus those receiving nonstandard antibiotics.

Data were included from 21,358 hysterectomies. The researchers found that the overall rate of any surgical site infection was 2.06 percent. For any surgical site infection, the unadjusted rates were 1.8, 3.1, and 3.7 percent, respectively, for those receiving β-lactam, β-lactam alternatives, and nonstandard antibiotics. Compared with the β-lactam antibiotics (reference group), the risk of any surgical site infection was increased for those receiving β-lactam alternatives or the nonstandard antibiotics (odds ratios, 1.7 and 2.0, respectively), after adjustment for patient and operative factors within clusters of hospitals.

"Efforts to decrease surgical site infections could focus on adherence to recommended preoperative antibiotic guidelines and thorough evaluation of patient-reported penicillin allergies to increase the number of patients receiving β-lactam antibiotics," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »