Prolactin Receptor Signaling Linked to Expansion of β-Cells

Share this content:
Prolactin Receptor Signaling Linked to Expansion of β-Cells
Prolactin Receptor Signaling Linked to Expansion of β-Cells

THURSDAY, May 26, 2016 (HealthDay News) -- Prolactin receptor (PRLR) signaling plays a role in expansion of maternal β-cells during pregnancy, according to a study published online May 23 in Diabetes.

Ronadip R. Banerjee, M.D., from the Stanford University School of Medicine in California, and colleagues generated a 'floxed' Prlr allele that allowed conditional loss of PRLR in β-cells in order to examine the in vivo requirement for PRLR signaling.

The researchers found that PRLR signaling loss in β-cells resulted in gestational diabetes mellitus (GDM), and in reduced proliferation of β-cells and failure to expand β-cell mass during pregnancy. Expression of the transcription factor Foxm1, both G1/S and G2/M cyclins, tryptophan hydroxylase 1, and islet serotonin production were impaired with targeted PRLR loss in maternal β-cells in vivo. PRLR signaling was also required for the transient gestational expression of the MafB transcription factor within a subset of β-cells in pregnancy. GDM was also produced with deletion of MafB in maternal β-cells; inadequate β-cell expansion was accompanied by failure to induce PRLR-dependent target genes, which regulate proliferation of β-cells.

"These results unveil molecular roles for PRLR signaling in orchestrating the physiologic expansion of maternal β-cells during pregnancy," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Post-C-Section Cephalexin, Metronidazole Cuts SSI Rate

Post-C-Section Cephalexin, Metronidazole Cuts SSI Rate

Post-op course reduces rate of surgical site infection within 30 days of C-section among obese women

Multicomponent Intervention Linked to Greater Drop in BP

Multicomponent Intervention Linked to Greater Drop in BP

Intervention beneficial over 18 months for low-income adults in Argentina with uncontrolled HTN

Total of 0.21 Years Lost Due to Opioid-Related Poisoning Deaths

Total of 0.21 Years Lost Due to Opioid-Related ...

Drug-related poisoning deaths up from 2000 to 2015, with most of the increase due to opioid deaths

is free, fast, and customized just for you!

Already a member?

Sign In Now »