Proinsulin-to-C-Peptide Ratio Linked to Progression to T1DM

Share this content:
Proinsulin-to-C-Peptide Ratio Linked to Progression to T1DM
Proinsulin-to-C-Peptide Ratio Linked to Progression to T1DM

TUESDAY, July 19, 2016 (HealthDay News) -- Elevation in the serum proinsulin-to-C-peptide (PI:C) ratio is associated with progression to type 1 diabetes, according to a study published online July 6 in Diabetes Care.

Emily K. Sims, M.D., from the Indiana University School of Medicine in Indianapolis, and colleagues examined whether elevation in the PI:C ratio correlated with type 1 diabetes. Samples were obtained about 12 months before onset of diabetes from 60 TrialNet Pathway to Prevention progressors in whom diabetes developed and 58 age-, sex-, and body mass index (BMI)-matched nonprogressors who remained normoglycemic.

The researchers found that, compared with nonprogressors, there was a significant increase in PI:C ratios in antibody-positive subjects in whom there was progression to diabetes (median, 1.81 versus 1.17 percent; P = 0.03). Subjects who were ≤10 years old had the most pronounced difference between groups; 90 percent of subjects in this age group within the upper PI:C ratio quartile progressed to diabetes development. The odds of progression were increased for higher natural log PI:C ratio values after adjustment for age and BMI (odds ratio, 1.44).

"These data suggest that β-cell endoplasmic reticulum dysfunction precedes type 1 diabetes onset, especially in younger children," the authors write. "Elevations in the serum PI:C ratio may have utility in predicting the onset of type 1 diabetes in the presymptomatic phase."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »