Process Promising for On-Site Printing of Custom-Dosed Meds

Share this content:
Process Promising for On-Site Printing of Custom-Dosed Meds
Process Promising for On-Site Printing of Custom-Dosed Meds

WEDNESDAY, Oct. 4, 2017 (HealthDay News) -- Small molecular medicines can be printed precisely using organic vapor jets, according to a study published online Sept. 27 in Nature Communications.

Olga Shalev, Ph.D., from the University of Michigan in Ann Arbor, and colleagues discussed the potential use of solvent-free organic vapor jets to print small molecular medicines.

The researchers found that nanostructured films of small molecular pharmaceutical ingredients could be deposited by use of solvent-free organic vapor jet printing; these ingredients included caffeine, acetaminophen, ibuprofen, tamoxifen, BAY 11-7082, and fluorescein. Accuracy was on the scale of µg per cm². The pharmaceutical ingredients could be printed onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles. Similar crystallographic order and chemistry was demonstrated by the printed films and the original powders; relative to powder-form particles, controlled, order-of-magnitude enhancements of dissolution rate were observed. In vitro treatment of breast and ovarian cancer cell cultures in aqueous media by tamoxifen and BAY 11-7082 films showed similar behavior to drugs pre-dissolved in dimethyl sulfoxide.

"The ability to deposit small molecular drugs from their pure form, as films and without the use of solvents as shown here, opens an alternative approach to drug screening and manufacturing, where accurate dosage, chemical and structural stability, and processing flexibility are needed without hindering drug functionality," the authors write. "The technique demonstrated here also potentially enables continuous manufacturing, eliminating the need for mixing and powder preparation."

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Out-of-Pocket Expenditures Down With ACA Implementation

Out-of-Pocket Expenditures Down With ACA Implementation

Reduced out-of-pocket costs seen especially for lower-income groups; mean premium costs up overall

Gynecologic Complications Up With Hysteroscopic Sterilization

Gynecologic Complications Up With Hysteroscopic Sterilization

But lower risk of surgical and medical complications versus laparoscopic sterilization

Prevalence of Cigarette Smoking 15.5 Percent in 2016

Prevalence of Cigarette Smoking 15.5 Percent in 2016

Increase in percentage of ever smokers who quit during 2005 to 2016, from 50.8 to 59 percent

is free, fast, and customized just for you!

Already a member?

Sign In Now »