Probiotic Mixture VSL#3 Shows Promise for Crohn's Recurrence

This article originally appeared here.
Share this content:
Probiotic Mixture VSL#3 Shows Promise for Crohn's Recurrence
Probiotic Mixture VSL#3 Shows Promise for Crohn's Recurrence

(HealthDay News) -- The probiotic VSL#3, which includes eight different bacterial probiotic species, may be beneficial for preventing Crohn's disease recurrence, according to a study published in the May issue of Clinical Gastroenterology and Hepatology.

Richard N. Fedorak, M.D., from the University of Alberta in Edmonton, Canada, and colleagues examined the ability of VSL#3 to prevent Crohn's disease recurrence after surgery. Patients were randomized to groups given one sachet of VSL#3 (59 patients) or matching placebo (60 patients) within 30 days of ileocolonic resection and re-anastomosis. Patients from both groups with no or mild endoscopic resection at day 90 received VSL#3 through 12 months.

The researchers observed no significant difference in the proportion of patients with severe endoscopic lesions for VSL#3 and placebo at day 90 (9.3 and 15.7 percent, respectively; P = 0.19). The proportions of patients with non-severe lesions at day 90 who had severe endoscopic recurrence were 10.0 and 26.7 percent, respectively, for those in the early VSL#3 group and late VSL#3 group (P = 0.09). There was no statistical difference between the aggregate rates of severe recurrence (on days 90 and 365). At day 90, patients receiving VSL#3 had reduced mucosal inflammatory cytokine levels (P < 0.05).

"Lower mucosal levels of inflammatory cytokines and a lower rate of recurrence among patients who received early VSL#3 (for the entire 365 days) indicate that this probiotic should be further investigated," the authors write.

One author disclosed financial ties to VSL Pharmaceuticals, the manufacturer of VSL#3.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Dupilumab Reduces Rate of Severe Asthma Exacerbations

Dupilumab Reduces Rate of Severe Asthma Exacerbations

And, add-on dupilumab reduces glucocorticoid dose in patients with glucocorticoid-treated asthma

Better Social Support Network Protects Black Men Against HIV

Better Social Support Network Protects Black Men Against ...

Social networks of black men who have sex with men influence HIV risk behavior

Recommendations Developed for Managing Postpartum Pain

Recommendations Developed for Managing Postpartum Pain

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

is free, fast, and customized just for you!

Already a member?

Sign In Now »