Prenatal BPA Exposure May Dampen Body's Fullness Cues

Share this content:
Prenatal BPA Exposure May Dampen Body's Fullness Cues
Prenatal BPA Exposure May Dampen Body's Fullness Cues

WEDNESDAY, Feb. 8, 2017 (HealthDay News) -- Prenatal exposure to bisphenol A (BPA) may raise a child's risk of obesity by altering hypothalamic circuits that regulate feeding behavior and energy balance, according to an experimental study published online Feb. 7 in Endocrinology.

Harry MacKay, Ph.D., from the Baylor College of Medicine in Houston, and colleagues examined leptin sensitivity and hypothalamic structure in young BPA-exposed animals before onset of a body weight or metabolic phenotype. They exposed pregnant and lactating CD-1 mice to BPA or diethylstilbestrol (DES) at low, environmentally relevant doses.

The researchers found that young adult offspring were resistant to leptin-induced suppression of food intake, body weight loss, and hypothalamic pro-opiomelanocortin (POMC) upregulation. Reduced density of POMC projections into the paraventricular hypothalamus (PVN) was seen for male and female BPA-exposed mice. BPA- and DES-exposed pups had delayed and blunted postnatal leptin surges, respectively; in female BPA-exposed animals given daily injections of supplemental leptin, POMC projections into the PVN were rescued.

"Our findings suggest that BPA, a putative obesogen, may exert its effects through developmental programming of the hypothalamic melanocortin circuitry, permanently altering the neurobiology of metabolic homeostasis," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

FDA Approves Bavencio for Merkel Cell Carcinoma

FDA Approves Bavencio for Merkel Cell Carcinoma

Drug targets the PD-1/PD-L1 pathway; first sanctioned treatment in the United States

Heterogeneous Association for Alcohol, CVD Presentation

Heterogeneous Association for Alcohol, CVD Presentation

Non-drinking linked to increased risks of unstable angina, MI, heart failure, ischemic stroke, PAD, AAA

Mobile App Cuts In-Person Visits After Breast Reconstruction

Mobile App Cuts In-Person Visits After Breast Reconstruction

Number of visits down, increase in e-mails to doctors for ambulatory patients undergoing breast recon

is free, fast, and customized just for you!

Already a member?

Sign In Now »