Pregabalin Significantly Improves Neuropathic Pain

This article originally appeared here.
Share this content:
Pregabalin Significantly Improves Neuropathic Pain
Pregabalin Significantly Improves Neuropathic Pain

FRIDAY, Sept. 9, 2016 (HealthDay News) -- Pregabalin significantly improves neuropathic pain, irrespective of the time since pain onset, according to a study published online Sept. 2 in Pain Practice.

Concepción Pérez, Ph.D., from the Hospital de la Princesa in Madrid, and colleagues conducted a pooled analysis of 19 randomized placebo-controlled trials of pregabalin for peripheral neuropathic pain conditions (including diabetic peripheral neuropathy, postherpetic neuralgia, and posttraumatic/postsurgical pain). Patients were divided into five categories according to time since onset of pain. For each category, the mean change in pain score at end point was assessed versus placebo. Data were included for 5,783 patients (3,619 pregabalin-treated and 2,164 placebo-treated).

The researchers found that across pain duration categories, the mean baseline pain scores were similar. In all patients together, pregabalin significantly improved pain score at end point versus placebo (treatment difference, −0.59); similar results were seen in each pain duration category. Significantly more Patient Global Impression of Change responders were seen with pregabalin versus placebo for all patients (45 versus 30.9 percent) and for each category separately. No consistent, significant differences in treatment response were seen between the different categories of pain duration.

"Pregabalin significantly improves pain irrespective of the length of time since onset of neuropathic pain," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Pfizer, which manufactures pregabalin and funded the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Disabling Injury, Illness Less Likely for Elderly Who Exercise

Disabling Injury, Illness Less Likely for Elderly Who ...

And likely to recover more quickly if injury or illness occurs

More Evidence of Abdominal Fat, Poor Cardiovascular Health Link

More Evidence of Abdominal Fat, Poor Cardiovascular Health ...

Adipose tissue imaging may outperform body mass index for cardiovascular risk assessment

is free, fast, and customized just for you!

Already a member?

Sign In Now »